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Article

Longitudinal analysis of genetic and epigenetic changes in human pluripotent stem cells in the landscape of culture-induced abnormality.

Experimental & molecular medicine - 1 Nov 2024

Kim Yun-Jeong, Kang Byunghee, Kweon Solbi, Oh Sejin, Kim Dayeon, Gil Dayeon, Lee Hyeonji, Kim Jung-Hyun, Ju Ji Hyeon, Roh Tae-Young, Hong Chang Pyo, Cha Hyuk-Jin

Abstract excerpt

Human embryonic stem cells (hESCs) are naturally equipped to maintain genome integrity to minimize genetic mutations during early embryo development. However, genetic aberration risks and subsequent cellular changes in hESCs during in vitro culture pose a significant threat to stem cell therapy. While a few studies have reported specific somatic mutations and copy number variations (CNVs), the molecular...

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Identifiers

PMID: 39482531
DOI: 10.1038/s12276-024-01334-8
PMCID: PMC11612254

Genes

BCL2L1
TP53
TPX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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