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The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells

19 Nov 2021

Abstract excerpt

Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of cells, in both the undifferentiated and differentiated state. Currently, very little is known on how these abnormalities will impact the clinical translation of hPSC,...

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PMID: 34831467
DOI: 10.3390/cells10113246

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