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Article

Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research.

Stem cell reports - 9 Jan 2024

Krivec Nuša, Ghosh Manjusha S, Spits Claudia

Abstract excerpt

The genetic abnormalities observed in hPSC cultures worldwide have been suggested to pose an important hurdle in their safe use in regenerative medicine due to the possibility of oncogenic transformation by mutant cells in the patient posttransplantation. One of the best-characterized genetic lesions in hPSCs is the gain of 20q11.21, found in 20% of hPSC lines worldwide, and strikingly, also amplified in 20% of...

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Identifiers

PMID: 38157850
DOI: 10.1016/j.stemcr.2023.11.013
PMCID: PMC10828824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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