Article

Cytogenetic resource enables mechanistic resolution of changing trends in human pluripotent stem cell aberrations linked to feeder-free culture

2023-09-21

Abstract excerpt

<h4>Summary</h4> Since the first derivation of human pluripotent stem cells (hPSCs), the number of culture conditions has steadily increased, making hPSC culture more facile. Nonetheless, there remains the persistent issue of culture-acquired genetic changes, hampering the reproducibility of hPSC research and jeopardising their clinical use. Here, we utilised comprehensive karyotyping datasets from over 20,000 hP...

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Literature Corpus work: 7485e104-3c5f-54b9-b6fa-89a22368be8f
DOI: 10.1101/2023.09.21.558777

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