Article

Sequential genetic and epigenetic alterations in human pluripotent stem cells for recurrent abnormality

2023-12-18

Abstract excerpt

Human embryonic stem cells (hESCs) are naturally equipped to maintain genome integrity to minimize genetic mutations during early embryo development. However, genetic aberration risks and subsequent cellular changes in hESCs during in vitro culture pose a significant threat to stem cell therapy. While a few studies have reported specific somatic mutations and copy number variations (CNVs), the molecular mechanism...

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Literature Corpus work: 2ff5dc02-06f9-5585-a895-89f7f6d4770c
DOI: 10.1101/2023.12.17.572095

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