Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.

Nature biotechnology - 1 Dec 2008

Lefort Nathalie, Feyeux Maxime, Bas Cécile, Féraud Olivier, Bennaceur-Griscelli Annelise, Tachdjian Gerard, Peschanski Marc, Perrier Anselme L

Abstract excerpt

By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing approximately 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 20
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Gene Amplification

Share to Genomic Instability

Share to In Situ Hybridization, Fluorescence

Share to Oligonucleotide Array Sequence Analysis

Share to Recurrence

Source

Identifiers

PMID: 19029913
DOI: 10.1038/nbt.1509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human embryonic stem cells reveal recurrent genomic instability at 20q11.21.PMID 19029913Read ↗

De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture.Semantic proximity Read ↗

<i>De novo</i> cancer mutations frequently associate with recurrent chromosomal abnormalities during long-term human pluripotent stem cell cultureSemantic proximity Read ↗

Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research.Semantic proximity Read ↗

Sequential genetic and epigenetic alterations in human pluripotent stem cells for recurrent abnormalitySemantic proximity Read ↗

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.Semantic proximity Read ↗

BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures.Semantic proximity Read ↗

Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future ChallengesSemantic proximity Read ↗

Longitudinal analysis of genetic and epigenetic changes in human pluripotent stem cells in the landscape of culture-induced abnormality.Semantic proximity Read ↗

Inherent genome instability underlies trisomy 21-associated myeloid malignanciesSemantic proximity Read ↗

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.Semantic proximity Read ↗

Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations.Semantic proximity Read ↗

Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-β-Dependent Neuroectodermal CommitmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.