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Article

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.

Nature biotechnology - 1 Apr 2010

Närvä Elisa, Autio Reija, Rahkonen Nelly, Kong Lingjia, Harrison Neil, Kitsberg Danny, Borghese Lodovica, Itskovitz-Eldor Joseph, Rasool Omid, Dvorak Petr, Hovatta Outi, Otonkoski Timo, Tuuri Timo, Cui Wei, Brüstle Oliver, Baker Duncan, Maltby Edna, Moore Harry D, Benvenisty Nissim, Andrews Peter W, Yli-Harja Olli, Lahesmaa Riitta

Abstract excerpt

Prolonged culture of human embryonic stem cells (hESCs) can lead to adaptation and the acquisition of chromosomal abnormalities, underscoring the need for rigorous genetic analysis of these cells. Here we report the highest-resolution study of hESCs to date using an Affymetrix SNP 6.0 array containing 906,600 probes for single nucleotide polymorphisms (SNPs) and 946,000 probes for copy number variations (CNVs)....

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PMID: 20351689
DOI: 10.1038/nbt.1615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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