Article

Enhanced Effector Activity of Mediator Kinase Module Deficient CAR-T Cells

2022-09-04

Abstract excerpt

Adoptive T cell immune therapies mediate impressive clinical benefit in a fraction of patients, but anti-tumor effects are often limited by inadequate T cell potency. To identify genes limiting T cell effector function, we conducted genome-wide CRISPR knock-out screens in human primary CAR-T cells. The top hits were MED12 and CCNC , components of the cyclin-dependent kinase (CDK) module of the Mediator complex,...

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Literature Corpus work: d5eeb574-df1f-5a96-a3a9-0bb79c95e3a6
DOI: 10.1101/2022.09.02.506235

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