Article

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function

2023-05-01

Abstract excerpt

The clinical response to adoptive T cell therapies is strongly associated with transcriptional and epigenetic state. Thus, technologies to discover regulators of T cell gene networks and their corresponding phenotypes have great potential to improve the efficacy of T cell therapies. We developed pooled CRISPR screening approaches with compact epigenome editors to systematically profile the effects of activation an...

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Literature Corpus work: 948a6329-9227-5647-b36d-5c7eedf13670
DOI: 10.1101/2023.05.01.538906

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