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Article

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

27 Jan 2020

Abstract excerpt

The Mediator kinase module regulates eukaryotic transcription by phosphorylating transcription-related targets and by modulating the association of Mediator and RNA polymerase II. The activity of its catalytic core, cyclin-dependent kinase 8 (CDK8), is controlled by Cyclin C and regulatory subunit MED12, with its deregulation contributing to numerous malignancies. Here, we combine in vitro biochemistry,...

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PMID: 31988137
DOI: 10.1073/pnas.1917635117

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