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Article

Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseases

10 Nov 2020

Abstract excerpt

Transcriptional dysregulation is central to many diseases including cancer. Mutation or deregulated expression of proteins involved in transcriptional machinery leads to aberrant gene expression that disturbs intricate cellular processes of division and differentiation. The subunits of the mediator complex are master regulators of stimuli-derived transcription and are essential for transcription by RNA polymerase...

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PMID: 33174211
DOI: 10.1002/jcp.30099

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