Article

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells

2026-01-29

Abstract excerpt

Precise modulation of T cell function through engineering the non-coding genome holds great promise for advancing next-generation immunotherapies. However, robust high-throughput approaches to annotate functional cis-regulatory elements (CRE) in human T cells remain limited. Here, we developed a simple and highly efficient CRISPR interference (CRISPRi) perturbation platform to systematically annotate CREs in human...

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Identifiers and source

Literature Corpus work: 94a49103-5ef8-5543-bea8-9504402d16ba
DOI: 10.64898/2026.01.27.702006

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