Article

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

2024-11-19

Abstract excerpt

Chimeric antigen receptor (CAR) T cells are highly effective in hematologic malignancies. However, loss of CAR T cells can contribute to relapse in a significant number of patients. These limitations could potentially be overcome by targeted gene editing to increase CAR T cell persistence. Here, we performed in vivo loss-of-function CRISPR screens in BCMA-targeting CAR T cells to investigate genes that influence...

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Literature Corpus work: da4c767b-30d9-5cd9-8368-c17f9bba59ce
DOI: 10.1101/2024.11.19.624352

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