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Article

Mediator kinase module and human tumorigenesis

16 Jul 2015

Abstract excerpt

Mediator is a conserved multi-subunit signal processor through which regulatory informatiosn conveyed by gene-specific transcription factors is transduced to RNA Polymerase II (Pol II). In humans, MED13, MED12, CDK8 and Cyclin C (CycC) comprise a four-subunit "kinase" module that exists in variable association with a 26-subunit Mediator core. Genetic and biochemical studies have established the Mediator kinase...

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Identifiers

PMID: 26182352
DOI: 10.3109/10409238.2015.1064854

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