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Article

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

15 Jan 2021

Abstract excerpt

CKM that redefines prior CKM structural models and explains the mechanism of Med12-dependent Cdk8 activation. Med12 interacts extensively with CycC and activates Cdk8 by stabilizing its activation (T-)loop through conserved Med12 residues recurrently mutated in human tumors. Unexpectedly, Med13 has a characteristic Argonaute-like bi-lobal architecture. These findings not only provide a structural basis for...

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PMID: 33523904
DOI: 10.1126/sciadv.abd4484

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