Article

MTBP allosterically activates Cdk8-CycC kinase activity

2025-06-19

Abstract excerpt

How the approximately 300 human protein kinases identify their dedicated substrates despite the significant overlap of their phosphorylation consensus sequences is relevant for nearly all cellular processes. We show here that the Cdk8/19-CycC kinase uses mutually exclusive targeting and activation factors to facilitate distinct cellular roles. The Med12 protein is known to target Cdk8/19-CycC to the mediator of tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a37d818-3839-55c8-b7b5-11d4e9837f40
DOI: 10.1101/2025.06.16.659917

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MTBP allosterically activates Cdk8-CycC kinase activityDOI 10.1101/2025.06.16.659917Read

A precisely positioned MED12 activation helix stimulates CDK8 kinase activitySemantic proximity Read

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase moduleSemantic proximity Read

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.Semantic proximity Read

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase ModulesSemantic proximity Read

CDK9 as an Appealing Target for Therapeutic InterventionsSemantic proximity Read

The two faces of Cdk8, a positive/negative regulator of transcription.Semantic proximity Read

Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKsSemantic proximity Read

Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseasesSemantic proximity Read

CDK9: A key player in cancer and other diseasesSemantic proximity Read

CDK12: cellular functions and therapeutic potential of versatile player in cancerSemantic proximity Read

PAF1C allosterically activates CDK12/13 kinase during RNAPII transcript elongationSemantic proximity Read

Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK ActivitySemantic proximity Read