Article
Genome-wide screens identify specific drivers of mutant hTERT promoters.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2022
Shanmugam Raghuvaran, Ozturk Mert Burak, Low Joo-Leng, Akincilar Semih Can, Chua Joelle Yi Heng, Thangavelu Matan Thangavelu, Periyasamy Giridharan, DasGupta Ramanuj, Tergaonkar Vinay
Abstract excerpt
Cancer-specific hTERT promoter mutations reported in 19% of cancers result in enhanced telomerase activity. Understanding the distinctions between transcriptional regulation of wild-type (WT) and mutant (Mut) hTERT promoters may open up avenues for development of inhibitors which specially block hTERT expression in cancer cells. To comprehensively identify physiological regulators of WT- or Mut-hTERT promoters,...
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