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Article

The emerging role of mediator complex subunit 12 in tumorigenesis and response to chemotherapeutics.

Cancer - 1 Mar 2020

Zhang Shengjie, O'Regan Ruth, Xu Wei

Abstract excerpt

Transcriptional dysregulation induced by disease-defining genetic alterations of proteins in transcriptional machinery is a key feature of cancers. Mediator complex subunit 12 (MED12) is the central architectural subunit in the kinase module of Mediator, a large transcriptional regulatory complex that controls essential steps of transcription. Emerging evidence links deregulated MED12 to human cancers. MED12 is...

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Identifiers

PMID: 31869450
DOI: 10.1002/cncr.32672
PMCID: PMC7021580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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