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Article

Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules

13 Jan 2019

Abstract excerpt

CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module. This module reversibly associates with the Mediator, a 26 subunit protein complex that...

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PMID: 30693281
DOI: 10.3389/fcell.2018.00171

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