Article

Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

2020-09-29

Abstract excerpt

The compact CRISPR/Cas9 system, which can be delivered by adeno-associated virus (AAV), is a promising platform for therapeutic applications. However, current compact Cas9 nucleases have limited activity, targeting scope and specificity. Here, we identified three compact SaCas9 orthologs, Staphylococcus lugdunensis Cas9 (SlugCas9), Staphylococcus lutrae Cas9 (SlutrCas9) and Staphylococcus haemolyticus Cas9 (Sha...

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Identifiers and source

Literature Corpus work: d56a3915-4e80-575b-bda0-a65429f09b10
DOI: 10.1101/2020.09.29.316661

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