Article

Multi-ancestry polygenic risk scores using phylogenetic regularization

2024-02-17

Abstract excerpt

Accurately predicting phenotype using genotype across diverse ancestry groups remains a significant challenge in human genetics. Many state-of-the-art polygenic risk score models are known to have difficulty generalizing to genetic ancestries that are not well represented in their training set. To address this issue, we present a novel machine learning method for fitting genetic effect sizes across multiple ancest...

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Literature Corpus work: d523cdcf-6e31-53a2-b577-4b3bbbfaffa5
DOI: 10.1101/2024.02.14.580313

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