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Article

Optimal strategies for learning multi-ancestry polygenic scores vary across traits.

Nature communications - 7 Jul 2023

Lehmann Brieuc, Mackintosh Maxine, McVean Gil, Holmes Chris

Abstract excerpt

Polygenic scores (PGSs) are individual-level measures that aggregate the genome-wide genetic predisposition to a given trait. As PGS have predominantly been developed using European-ancestry samples, trait prediction using such European ancestry-derived PGS is less accurate in non-European ancestry individuals. Although there has been recent progress in combining multiple PGS trained on distinct populations, the...

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PMID: 37419925
DOI: 10.1038/s41467-023-38930-7
PMCID: PMC10328935

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