Article

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a Model

2018-11-29

Abstract excerpt

<h4>Background</h4> Understanding the nature of the genetic regulation of gene expression promises to advance our understanding of the genetic basis of disease. However, the methodological impact of use of local ancestry on high-dimensional omics analyses, including most prominently expression quantitative trait loci (eQTL) mapping and trait heritability estimation, in admixed populations remains critically under...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc4450be-d27c-59dc-b046-cff462451c74
DOI: 10.1101/483107

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelDOI 10.1101/483107Read

Leveraging the local genetic structure for trans-ancestry association mapping.Semantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read

Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populationsSemantic proximity Read

Causal effects on complex traits are similar across segments of different continental ancestries within admixed individualsSemantic proximity Read

Leveraging the local genetic structure for trans-ancestry association mappingSemantic proximity Read

Leveraging local ancestry to detect gene-gene interactions in genome-wide data.Semantic proximity Read

An ancestry-based approach for detecting interactions.Semantic proximity Read

Impact of cross-ancestry genetic architecture on GWASs in admixed populations.Semantic proximity Read

Leveraging local ancestry and cross-ancestry genetic architecture to improve genetic prediction of complex traits in admixed populations.Semantic proximity Read

Improved multi-ancestry fine-mapping identifies<i>cis</i>-regulatory variants underlying molecular traits and disease riskSemantic proximity Read

Estimating heritability and its enrichment in tissue-specific gene sets in admixed populationsSemantic proximity Read

Impact of cross-ancestry genetic architecture on GWAS in admixed populationsSemantic proximity Read