Article

An Ensemble Penalized Regression Method for Multi-ancestry Polygenic Risk Prediction

2023-03-16

Abstract excerpt

Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve the prediction of complex traits and diseases. However, most existing PRS are primarily trained on European ancestry populations, limiting their transferability to non-European populations. In this article, we propose a novel method for generating multi-ancestry Polygenic Risk scOres based on enSemble of PEnalized Regression mo...

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Literature Corpus work: 79b9f68b-5800-53bb-8a92-350d80ec0b66
DOI: 10.1101/2023.03.15.532652

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