Article

Inclusion of Variants Discovered from Diverse Populations Improves Polygenic Risk Score Transferability

2020-05-24

Abstract excerpt

<h4>ABSTRACT</h4> The majority of polygenic risk scores (PRS) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRS that contribute to this issue and determining solutions is complicated by disease-specific genetic architecture and limited knowledge of sharing of causal variants and effect sizes...

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Literature Corpus work: a4c4cf12-10bf-5cbc-9721-23db61202c4d
DOI: 10.1101/2020.05.21.108845

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