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MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups.

Cell genomics - 10 Apr 2024

Jin Jin, Zhan Jianan, Zhang Jingning, Zhao Ruzhang, O'Connell Jared, Jiang Yunxuan, Buyske Steven, Gignoux Christopher, Haiman Christopher, Kenny Eimear E, Kooperberg Charles, North Kari, Koelsch Bertram L, Wojcik Genevieve, Zhang Haoyu, Chatterjee Nilanjan

Abstract excerpt

Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide variety of complex traits and diseases, but there exists a substantial performance gap across populations. We propose MUSSEL, a method for ancestry-specific polygenic prediction that borrows information in summary statistics from genome-wide association studies (GWASs) across multiple ancestry groups via Bayesian hierarchical...

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PMID: 38604127
DOI: 10.1016/j.xgen.2024.100539
PMCID: PMC11019365

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