Article

Hardwired synthetic lethality within the cohesin complex in human cancer cells

2017-04-08

Abstract excerpt

Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2 , displays a strong synthetic lethal interaction with its paralog STAG1 . Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catast...

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Literature Corpus work: d4ff7ffe-2ab1-56de-b037-d9551bbca043
DOI: 10.1101/125708

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