Article

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring <i>STAG2</i> mutations

2022-02-20

Abstract excerpt

Targeted therapies exploiting selective vulnerabilities of malignant cells are highly desired for clinical applications. The cohesin protein complex comprises of RAD21, SMC3, SMC1A as well as a fourth subunit that consists of either STAG1 or STAG2 and is essential for proper chromosomal segregation during mitosis. STAG2 loss-of-function mutations are recurrent driver events in acute myeloid leukemia (AML) and app...

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Literature Corpus work: 4ba44b04-efc1-56e9-8f8e-f21f420dfd62
DOI: 10.1101/2022.02.18.479480

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