Article
Mutational inactivation of STAG2 causes aneuploidy in human cancer.
Science (New York, N.Y.) - 19 Aug 2011
Solomon David A, Kim Taeyeon, Diaz-Martinez Laura A, Fair Joshlean, Elkahloun Abdel G, Harris Brent T, Toretsky Jeffrey A, Rosenberg Steven A, Shukla Neerav, Ladanyi Marc, Samuels Yardena, James C David, Yu Hongtao, Kim Jung-Sik, Waldman Todd
Abstract excerpt
Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes. We have identified a clue to the mechanistic origins of aneuploidy through integrative genomic analyses of human tumors. A diverse range of tumor types were found to harbor deletions or inactivating mutations of STAG2, a gene encoding a subunit of the cohesin complex, which regulates the separation of sister chromatids during...
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