Article

STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme

2023-12-01

Abstract excerpt

<title>Abstract</title> <p>Inactivating mutations of genes encoding the cohesin complex are common in a wide range of human cancers. STAG2 is the most commonly mutated cohesin complex subunit. Here we report the impact of stable correction of endogenous, naturally occurring STAG2 mutations on gene expression, 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme (GBM). In two...

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Literature Corpus work: c8a21d26-852f-5e72-82ec-ba6431a9a0c1
DOI: 10.21203/rs.3.rs-3673198/v1

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