Article
Cohesin Mutations in Cancer.
Cold Spring Harbor perspectives in medicine - 1 Dec 2016
De Koninck Magali, Losada Ana
Abstract excerpt
Cohesin is a large ring-shaped protein complex, conserved from yeast to human, which participates in most DNA transactions that take place in the nucleus. It mediates sister chromatid cohesion, which is essential for chromosome segregation and homologous recombination (HR)-mediated DNA repair. Together with architectural proteins and transcriptional regulators, such as CTCF and Mediator, respectively, it...
Topics
- Animals
- Cell Cycle Proteins
- Chromosomal Proteins, Non-Histone
- Chromosome Segregation
- DNA Repair
- Gene Expression Regulation, Neoplastic
- Humans
- Mice
- Multiprotein Complexes
- Mutation
- Neoplasms
- Sister Chromatid Exchange