Cohesin mutations and chromatin changes in cancer.

Abstract excerpt

The identification of recurrent mutations in genes encoding the cohesin complex in cancer was among the most unexpected findings from cancer exome sequencing studies. Cohesin is a multi-subunit protein complex that is essential for sister chromatid cohesion, three-dimensional chromosome organization, DNA damage repair, and gene regulation. It forms a ring around DNA, with four structural subunits, SMC1A, SMC3,...

Topics

• Humans
• Chromosomal Proteins, Non-Histone
• Cohesins
• Cell Cycle Proteins
• Neoplasms
• Mutation
• Chromatin