Article

Synthetic lethality between the cohesin subunits <i>STAG1</i> and <i>STAG2</i> in diverse cancer contexts

2017-06-25

Abstract excerpt

Recent genome analyses have identified recurrent mutations in the cohesin complex in a wide range of human cancers. Here we demonstrate that the most frequently mutated subunit of the cohesin complex, STAG2 , displays a strong synthetic lethal interaction with its paralog STAG1 . Mechanistically, STAG1 loss abrogates sister chromatid cohesion in STAG2 mutated but not in wild-type cells leading to mitotic catast...

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Literature Corpus work: 475987fd-9933-551d-b46b-3234b65b14b3
DOI: 10.1101/155309

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