Article

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cells

2020-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Cohesin exists in two variants, containing either STAG1 or STAG2. STAG2 is one of the most commonly mutated genes in human cancer, and a major bladder cancer tumor suppressor. Little is known about how its inactivation contributes to tumor development. Here, we analyze the genomic distribution of STAG1 and STAG2 and perform STAG2 loss-of-function experiments using RT112 bladder cancer cells; we...

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Literature Corpus work: aea17927-e8c5-5603-8cdb-c1c28ed908a8
DOI: 10.1101/2020.08.06.240457

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