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Article

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.

Nature genetics - 1 Dec 2013

Balbás-Martínez Cristina, Sagrera Ana, Carrillo-de-Santa-Pau Enrique, Earl Julie, Márquez Mirari, Vazquez Miguel, Lapi Eleonora, Castro-Giner Francesc, Beltran Sergi, Bayés Mònica, Carrato Alfredo, Cigudosa Juan C, Domínguez Orlando, Gut Marta, Herranz Jesús, Juanpere Núria, Kogevinas Manolis, Langa Xavier, López-Knowles Elena, Lorente José A, Lloreta Josep, Pisano David G, Richart Laia, Rico Daniel, Salgado Rocío N, Tardón Adonina, Chanock Stephen, Heath Simon, Valencia Alfonso, Losada Ana, Gut Ivo, Malats Núria, Real Francisco X

Abstract excerpt

Urothelial bladder cancer (UBC) is heterogeneous at the clinical, pathological and genetic levels. Tumor invasiveness (T) and grade (G) are the main factors associated with outcome and determine patient management. A discovery exome sequencing screen (n = 17), followed by a prevalence screen (n = 60), identified new genes mutated in this tumor coding for proteins involved in chromatin modification (MLL2, ASXL2...

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Source

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Identifiers

PMID: 24121791
DOI: 10.1038/ng.2799
PMCID: PMC3840052

Genes

STAG2
UBC
ASXL2
ATM
BPTF
ERCC2
FANCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.PMID 24121791Read ↗

The role of STAG2 in bladder cancer.Semantic proximity Read ↗

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Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes.Semantic proximity Read ↗

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cellsSemantic proximity Read ↗

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STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer.Semantic proximity Read ↗

Mutational inactivation of STAG2 causes aneuploidy in human cancer.Semantic proximity Read ↗

Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.Semantic proximity Read ↗

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