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Article

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.

PLoS genetics - 1 Feb 2016

Kim Jung-Sik, He Xiaoyuan, Orr Bernardo, Wutz Gordana, Hill Victoria, Peters Jan-Michael, Compton Duane A, Waldman Todd

Abstract excerpt

Somatic mutations of the cohesin complex subunit STAG2 are present in diverse tumor types. We and others have shown that STAG2 inactivation can lead to loss of sister chromatid cohesion and alterations in chromosome copy number in experimental systems. However, studies of naturally occurring human tumors have demonstrated little, if any, correlation between STAG2 mutational status and aneuploidy, and have further...

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Source

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Identifiers

PMID: 26871722
DOI: 10.1371/journal.pgen.1005865
PMCID: PMC4752446

Genes

STAG2
WAPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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