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Article

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML.

Journal of translational medicine - 3 Sept 2020

Smith James S, Lappin Katrina M, Craig Stephanie G, Liberante Fabio G, Crean Clare M, McDade Simon S, Thompson Alexander, Mills Ken I, Savage Kienan I

Abstract excerpt

BACKGROUND: The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), with STAG2 the most frequently mutated complex member. METHODS: Here we use functional genomics (RNA-seq, ChIP-seq and HiChIP) to investigate the impact of chronic STAG2...

Topics

Cell Cycle Proteins
Chromatin
Humans
Leukemia, Myeloid, Acute
Mutation
Myelodysplastic Syndromes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32883299
DOI: 10.1186/s12967-020-02500-y
PMCID: PMC7469420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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