Article

Lipid droplet accumulating microglia represent a dysfunctional and pro-inflammatory state in the aging brain

2019-08-06

Abstract excerpt

Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report a striking buildup of lipid droplets in microglia with aging in mouse and human brains. These cells, which we call lipid droplet-accumulating microglia (LAM), are defective in phagocytosis, produce high level...

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Literature Corpus work: 2a40c1eb-ac73-5d08-8eed-0e4612122c54
DOI: 10.1101/722827

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