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The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

2024-07-03

Abstract excerpt

Lipid changes in the brain have been implicated in many neurodegenerative diseases including Alzheimer’s Disease (AD), Parkinson’s disease and Amyotrophic Lateral Sclerosis. To facilitate comparative lipidomic research across brain-diseases we established a data commons named the Neurolipid Atlas, that we have pre-populated with novel human, mouse and isogenic induced pluripotent stem cell (iPSC)-derived lipidomic...

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Literature Corpus work
63ec8715-9bad-5658-b739-64f6fc9e1486
DOI
10.1101/2024.07.01.601474
Open publication

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The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4DOI 10.1101/2024.07.01.601474
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