Article

Phospholipid Composition of APOE Lipoproteins Affects Microglia Activation in an Isoform-specific Manner

2020-10-16

Abstract excerpt

<title>Abstract</title> <p>Apolipoprotein E4 (APOE) is the strongest genetic risk factor for Alzheimer’s disease (AD). Our lipidomic analysis identified a common phospholipid signature with a high level of correlation between APOEε3/3 and APOEε4/4 AD postmortem brain samples and native lipoproteins isolated from astrocyte conditioned media of mice expressing human APOE3 or APOE4. Behavioral testing demonstrated t...

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Literature Corpus work: 25c77a25-55e5-5795-89b2-55bf80147d42
DOI: 10.21203/rs.3.rs-83085/v1

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