Article

Genetic variation in<i>HIF1A</i>is associated with smoldering inflammation and disease progression in Multiple Sclerosis

2024-03-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Understanding the mechanisms underlying disease progression in Multiple Sclerosis (MS) is fundamental to pave the way to treatment advances. Smoldering demyelinating inflammation characterized by iron deposition is observed at the edges of chronic active lesions and represents a relevant substrate of disease progression in MS. However, the influence of genetic factors on these...

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Literature Corpus work: d3c3fec0-5d0f-5c90-b65c-285cb968e5f8
DOI: 10.1101/2024.03.15.24304290

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