Article

Enhanced Astrocyte Responses are Driven by a Genetic Risk Allele Associated with Multiple Sclerosis

2017-10-19

Abstract excerpt

Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090 G , located near NFKB1 , on astrocytes. We demonstrated that chromatin is accessible at the risk locus, a prerequisite for its impact on astrog...

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Literature Corpus work: 2e0ed9e3-b1a9-544c-916d-df378ae06109
DOI: 10.1101/206110

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