Article
Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis.
BMC medical genetics - 10 Aug 2012
Gemmati Donato, Zeri Giulia, Orioli Elisa, De Gaetano Francesca E, Salvi Fabrizio, Bartolomei Ilaria, D'Alfonso Sandra, Dall'osso Claudia, Leone Maurizio A, Singh Ajay V, Asselta Rosanna, Zamboni Paolo
Abstract excerpt
BACKGROUND: Iron involvement/imbalance is strongly suspected in multiple sclerosis (MS) etiopathogenesis, but its role is quite debated. Iron deposits encircle the veins in brain MS lesions, increasing local metal concentrations in brain parenchyma as documented by magnetic resonance imaging and histochemical studies. Conversely, systemic iron overload is not always observed. We explored the role of common single...
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