Article
Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jun 2021
Zuccalà Miriam, Barizzone Nadia, Boggio Elena, Gigliotti Luca, Sorosina Melissa, Basagni Chiara, Bordoni Roberta, Clarelli Ferdinando, Anand Santosh, Mangano Eleonora, Vecchio Domizia, Corsetti Elena, Martire Serena, Perga Simona, Ferrante Daniela, Gajofatto Alberto, Ivashynka Andrei, Solaro Claudio, Cantello Roberto, Martinelli Vittorio, Comi Giancarlo, Filippi Massimo, Esposito Federica, Leone Maurizio, De Bellis Gianluca, Dianzani Umberto, Martinelli-Boneschi Filippo, D'Alfonso Sandra
Abstract excerpt
Among multiple sclerosis (MS) susceptibility genes, the strongest non-human leukocyte antigen (HLA) signal in the Italian population maps to the TNFSF14 gene encoding LIGHT, a glycoprotein involved in dendritic cell (DC) maturation. Through fine-mapping in a large Italian dataset (4,198 patients with MS and 3,903 controls), we show that the TNFSF14 intronic SNP rs1077667 is the primarily MS-associated variant in...
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