Article

Genetic analysis of multiple sclerosis severity identifies a novel locus and implicates CNS resilience as a major determinant of outcome

2022-06-10

Abstract excerpt

<title>Abstract</title> <p>Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that results in significant neurodegeneration in the majority of those affected and is a common cause of chronic neurological disability in young adults. To provide insight into the mechanisms determining progression, we conducted a genome-wide association study of the age-related MS severity score in 1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5226ce8b-e7af-5285-addf-e0eda09ff043
DOI: 10.21203/rs.3.rs-1723574/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of multiple sclerosis severity identifies a novel locus and implicates CNS resilience as a major determinant of outcomeDOI 10.21203/rs.3.rs-1723574/v1Read

Unlocking Multiple Sclerosis GeneticsSemantic proximity Read

Genetic Prognostic Factors in Multiple Sclerosis: Key Discoveries and Unmet Needs.Semantic proximity Read

Not all roads lead to the immune system: the genetic basis of multiple sclerosis severitySemantic proximity Read

The genetic architecture of multiple sclerosis in 2026: From susceptibility to disease progression.Semantic proximity Read

A Genetic Risk Variant for Multiple Sclerosis Severity is Associated with Brain AtrophySemantic proximity Read

The genetics of multiple sclerosis: an updated perspective.Semantic proximity Read

Genome-wide association study of severity in multiple sclerosis.Semantic proximity Read

Not all roads lead to the immune system: The Genetic Basis of Multiple Sclerosis Severity Implicates Central Nervous System and Mitochondrial InvolvementSemantic proximity Read

GWAS highlights the neuronal contribution to multiple sclerosis susceptibilitySemantic proximity Read

Genetic modifiers of multiple sclerosis progression, severity and onset.Semantic proximity Read

Genetic model of MS severity predicts future accumulation of disabilitySemantic proximity Read

Contrasting genetic architectures of multiple sclerosis susceptibility and outcome phenotypes.Semantic proximity Read