Article

Multiplex immunohistochemistry of chronic active multiple sclerosis lesions links fibroblast-associated vessels with immune cell cuffs

2026-08-31

Abstract excerpt

<h4>Background: </h4> Multiple sclerosis (MS) is a chronic neurodegenerative disorder in which inflammatory demyelinating lesions affect the brain, optic nerve and spinal cord. MS lesion formation is accompanied by profound changes to blood vessels, including the density of PDGFRβ+ mural cells, historically identified as pericytes. Intriguingly, in recent years, single-cell and lineage tracing studies have shown t...

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Literature Corpus work: 517a9e74-80cb-5703-8961-f1c5c40fe0d2
DOI: 10.64898/2026.08.26.747283

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