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Article

Chronic low-grade inflammation, genetic susceptibility, and the risk of multiple sclerosis: a prospective cohort study.

Frontiers in immunology - 1 Jan 2026

Cai Yizhou, Bao Yujia, Li Yongxuan, Gu Jiawei, Ran Qingqing, Zhou Yibin, Dong Linjuan, Wang Dunjia, Zhao Xia, Cheng Yuping, He Dandan

Abstract excerpt

Background: Immune dysregulation is central to multiple sclerosis (MS) pathogenesis, yet prospective evidence linking peripheral low-grade inflammation (LGI) to MS risk remains limited and inconsistent. We investigated the association of LGI with incident MS risk and MS-related brain structural measures in a large prospective cohort. Methods: We analyzed data from 377,487 UK Biobank participants aged 40 to 69...

Read the complete abstract on PubMed

Topics

Humans
Male
Multiple Sclerosis
Female
Genetic Predisposition to Disease
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prospective Studies

Adult

Inflammation

Aged

Incidence

Risk Factors

Genetic Risk Score

Brain

Chronic Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42718728
DOI: 10.3389/fimmu.2026.1805464
PMCID: PMC13553424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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