Article
Genetic Contribution to Medium-Term Disease Activity in Multiple Sclerosis.
Molecular neurobiology - 1 Jan 2025
Mascia Elisabetta, Nale Valentina, Ferrè Laura, Sorosina Melissa, Clarelli Ferdinando, Chiodi Alice, Santoro Silvia, Giordano Antonino, Misra Kaalindi, Cannizzaro Miryam, Moiola Lucia, Martinelli Vittorio, Milanesi Luciano, Filippi Massimo, Mosca Ettore, Esposito Federica
Abstract excerpt
Multiple sclerosis (MS) is a complex disorder characterized by high heterogeneity in terms of phenotypic expression, prognosis and treatment response. In the present study, we aimed to explore the genetic contribution to MS disease activity at different levels: genes, pathways and tissue-specific networks. Two cohorts of relapsing-remitting MS patients who started a first-line treatment (n = 1294) were enrolled...
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