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Article

Dysregulated Microglial Synaptic Engulfment in Diffuse Midline Glioma

2025-12-25

Abstract excerpt

<h4>SUMMARY</h4> Diffuse midline glioma (DMG) is a near-universally lethal form of pediatric high-grade glioma, driven by neuronal activity-regulated paracrine signaling and synaptic integration of malignant cells into neural circuits. In turn, DMG increases neuronal excitability, augmenting neuron-to-glioma signaling. In the healthy brain, microglia, the resident immune cells of the central nervous system (CNS),...

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Literature Corpus work
d3bb26cb-4a78-5c83-aa68-95aca65210b3
DOI
10.64898/2025.12.22.696064
Open publication

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