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Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

2024-09-23

Abstract excerpt

<h4>SUMMARY</h4> Neuronal activity promotes the proliferation of healthy oligodendrocyte precursor cells (OPC) and their malignant counterparts, gliomas. Many gliomas arise from and closely resemble oligodendroglial lineage precursors, including diffuse midline glioma (DMG), a cancer affecting midline structures such as the thalamus, brainstem and spinal cord. In DMG, glutamatergic and GABAergic neuronal activity...

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Identifiers and source

Literature Corpus work
e559ed78-1dd9-5aa0-8647-25af71ee13d8
DOI
10.1101/2024.09.21.614235
Open publication

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Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic SignalingDOI 10.1101/2024.09.21.614235
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